Lithium hydroxide, monohydrate → 3-Cyano-4-methoxybenzoic acid

HRID 385133

Reaktionsgleichung

Reaktionsgleichung von HRID 385133
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:6]([O:8]C)=[O:7])#[N:2].O.[OH-].[Li+]>O1CCCC1.O>[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:6]([OH:8])=[O:7])#[N:2]

Komponenten

5

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 2801011Methyl 3-cyano-4-methoxybenzoate

Produkt 1

HCID 219909723-Cyano-4-methoxybenzoic acidAusbeute 92,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Methyl 3-cyano-4-methoxybenzoate (879 mg) was dissolved in tetrahydrofuran (8 mL) and water (4 mL), and lithium hydroxide monohydrate (772 mg) was added to the solution, and then the mixture was stirred at mom temperature for 1 hour. The organic solvent was distilled off under reduced pressure and acidified with 2N hydrochloric acid, and then the precipitated crystal was collected by filtration to obtain the title compound (754 mg) as a colorless crystal.

Aufarbeitung

  1. distillationThe organic solvent was distilled off under reduced pressure
  2. filtrationthe precipitated crystal was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-afce05d383564db4869144b7ab6bb707
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367843B2

Verknüpfte Notizen

Wird geladen…