Water → HCID 57815430, Verbindung

Reaktionsgleichung

[Br:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]=[CH:7][CH:8]=[N+:9]([O-])[C:10]=2[CH:11]=1.C1(C)C=CC(S(Cl)(=O)=[O:20])=CC=1.C(=O)([O-])[O-].[K+].[K+].O>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](=[O:20])[NH:9]2)=[N:4][CH:3]=1

Komponenten

Edukt 4

HCID 962Water2×

HCID 73974-Toluenesulfonyl chloride

HCID 11430Potassium Carbonate

HCID 578152097-Bromo-1,5-naphthyridin-1-ium-1-olate

Produkt 1

HCID 57815430HCID 57815430, VerbindungAusbeute 78 %

Reagenzien, Katalysatoren, Lösungsmittel 1

Versuchsvorschrift

To a solution of 0.50 g of 3-bromo-1,5-naphthyridin-5-oxide in 10 mL of chloroform, 0.51 g of p-toluenesulfonyl chloride, 1.04 g of potassium carbonate and 3 mL of water were added, and the mixture was stirred at room temperature overnight. Thereto were added water and chloroform, and the solid was filtered off to obtain 0.39 g of 7-bromo-1,5-naphthyridin-2(1H)-one as a white solid.