Sodium borohydride → 1-(6-Bromo-2-pyridinyl)ethanol

HRID 385756Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 385756
[Br:1][C:2]1[N:7]=[C:6]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+]>CO.ClCCl.O>[Br:1][C:2]1[N:7]=[C:6]([CH:8]([OH:10])[CH3:9])[CH:5]=[CH:4][CH:3]=1

Komponenten

6

Edukt 2

HCID 4311764Sodium borohydrideHCID 112985782-Acetyl-6-bromopyridine

Produkt 1

HCID 110634791-(6-Bromo-2-pyridinyl)ethanol

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 1-(6-bromopyridin-2-yl)ethanone (2.9636 g, 14.82 mmol) in methanol (40 mL) at 0° C. was charged with sodium borohydride (1.682 g, 44.4 mmol) and then allowed to warm to room temperature. After 2.5 hours, the reaction mixture was diluted with dichloromethane (60 mL) and water (60 mL) and the layers were separated. The organic layer was dried over sodium sulfate, filtered, and concentrated to yield the title compound.

Aufarbeitung

  1. customthe layers were separated
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-7d668943413840dabfbdd461a0cf7016
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367706B2

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