Hydrochloric Acid → 5-azidopentanoic Acid

Temperatur

25 °C

To ethyl 5-azidovalerate (1.6 g; 10 mmol; Example 2.1) in 5 ml-dimethylformamide, was added lithium hydroxide (1.0 g; 20 mmol; Fisher) in 5 ml water, and the reaction mixture was stirred 12 h at 25° C. The reaction mixture was adjusted to pH ˜4 by addition of 1 N HCl and was extracted with 100 ml diethyl ether. The resulting organic layer was washed with water (100 ml) and brine (100 ml), dried over sodium sulfate, and dried in vacuo. Yield: 1.4 g (9.8 mmol, 99% yield).

1. extractionwas extracted with 100 ml diethyl ether
2. washThe resulting organic layer was washed with water (100 ml) and brine (100 ml)
3. dry with materialdried over sodium sulfate
4. customdried in vacuo

ORD-Eintrag

ord-5ca6025cb0c84ab8afc1e58f3fb6d681

Quelldatensatz

uspto-grants-2013_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08372839B2