1-(2,4-Xylyl)piperazine → 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(2,4-dimethylphenyl)piperazine

HRID 387125

Reaktionsgleichung

Reaktionsgleichung von HRID 387125
[C:1]([N:5]1[C:9]([CH2:10][CH2:11][CH:12]=O)=[CH:8][C:7]([CH2:14][CH2:15][CH3:16])=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[CH3:17][C:18]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:19]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1.CCN(C(C)C)C(C)C.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[C:1]([N:5]1[C:9]([CH2:10][CH2:11][CH2:12][N:28]2[CH2:29][CH2:30][N:25]([C:19]3[CH:20]=[CH:21][C:22]([CH3:24])=[CH:23][C:18]=3[CH3:17])[CH2:26][CH2:27]2)=[CH:8][C:7]([CH2:14][CH2:15][CH3:16])=[N:6]1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

5

Edukt 4

HCID 705441-(2,4-Xylyl)piperazineHCID 81531DiisopropylethylamineHCID 5049666Sodium triacetoxyborohydrideHCID 866399303-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propanal

Produkt 1

HCID 685587271-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(2,4-dimethylphenyl)piperazine

Versuchsvorschrift

164 mg (84%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propanal (100 mg, 0.450 mmol), 1-(2,4-dimethylphenyl)piperazine (86 mg, 0.450 mmol), DIPEA (0.118 mL, 0.675 mmol) and NaBH(OAc)3 (286 mg, 1.350 mmol).

Aufarbeitung

  1. custom164 mg (84%) of target compound was obtained

Quellen und Nachweise

ORD-Eintrag
ord-d52773c3fec946ac868556785c8ad318
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08372844B2

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