Acetic Acid → 8-(2-Methoxy-4-aminocarbonyl-phenyl)-1H,3H-purin-2,6-dione

HRID 3877Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 3877
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9](O)=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:18](=[O:21])[NH:17][C:16](=[O:22])[NH:15][C:14]=2[N:13]=1.[NH3:23].O.C(O)(=O)C>S(Cl)(Cl)=O.CN(C)C=O>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH2:23])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:18](=[O:21])[NH:17][C:16](=[O:22])[NH:15][C:14]=2[N:13]=1

Komponenten

8

Edukt 4

HCID 176Acetic AcidHCID 222AmmoniaHCID 962WaterHCID 13532361HCID 13532361, Verbindung

Produkt 1

HCID 201532438-(2-Methoxy-4-aminocarbonyl-phenyl)-1H,3H-purin-2,6-dione

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 6228DimethylformamideKatalysatorHCID 6228DimethylformamideLösungsmittel2×HCID 24386Thionyl ChlorideLösungsmittel2×

Versuchsvorschrift

A quantity of 2.3 gm of 8-(2-methoxy-4-carboxy-phenyl)-1H,-3H-purin-2,6-dione are refluxed for one hour in 50 ml of thionyl chloride with the addition of 1 drop of dimethylformamide. The excess thionyl chloride is drawn off, and the residue is stirred for 16 hours at ambient temperature with a solution of ammonia in dimethylformamide. The dimethylformamide is drawn off, the remainder is mixed with water and acidified with glacial acetic acid, and the product precipitated is filtered off.

Aufarbeitung

  1. customthe product precipitated
  2. filtrationis filtered off

Quellen und Nachweise

ORD-Eintrag
ord-6a823073ab7c4f51901f88aec89eb947
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04722929

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