Sodium Succinate → Cetirizine

HRID 390033

Reaktionsgleichung

Reaktionsgleichung von HRID 390033
[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]([N:15]2[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][O:23][CH2:24][C:25]([OH:27])=[O:26])[CH2:17][CH2:16]2)[C:8]2[CH:9]=[CH:10][C:11]([Cl:14])=[CH:12][CH:13]=2)=[CH:5][CH:6]=1.Cl.Cl.C(O)[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8CO)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO.C([O-])(=O)CCC([O-])=O.[Na+].[Na+]>O>[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]([N:15]2[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][O:23][CH2:24][C:25]([OH:27])=[O:26])[CH2:17][CH2:16]2)[C:8]2[CH:9]=[CH:10][C:11]([Cl:14])=[CH:12][CH:13]=2)=[CH:5][CH:6]=1

Komponenten

5

Edukt 3

HCID 9020Sodium SuccinateHCID 55182Cetirizine HydrochlorideHCID 444041beta-Cyclodextrin

Produkt 1

HCID 2678Cetirizine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

As indicated in Table 1, Cetirizine Dihydrochloride, Beta-cyclodextrin, Sodium Succinate, and Corn Starch are charged into a Fluid Bed Granulator. Approximately 3000 g of Purified Water is then sprayed into the bed at approximately 75-125 g/minute and an inlet air temperature of approximately 55° C., using an atomization air pressure of 2 bar. Approximately 5680 g of the solution prepared in Step A is then sprayed onto the granulation at approximately 75 to 125 g/minute, using an inlet air temperature of approximately 55° C., using an atomization air pressure of 2 bar. Following spraying, the granulation is dried to a product temperature endpoint of approximately 30° C., or a Loss on Drying Analysis (LOD) of approximately 7.5%.

Aufarbeitung

  1. additionare charged into a Fluid Bed Granulator
  2. customis then sprayed into the bed at approximately 75-125 g/minute and an inlet air temperature of approximately 55° C.
  3. customair temperature of approximately 55° C.
  4. customthe granulation is dried to a product temperature endpoint of approximately 30° C.
  5. customa Loss on Drying Analysis (LOD) of approximately 7.5%

Quellen und Nachweise

ORD-Eintrag
ord-bbdfdb99bd7c4473be69bb17d348e946
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08383632B2

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