4-Methylmorpholine → N-(tert-butoxycarbonyl)piperidine

HRID 392382

Reaktionsgleichung

Reaktionsgleichung von HRID 392382
CN1C[CH2:6][O:5]CC1.[CH3:8][CH:9]1[CH2:14]C(C)CN[CH2:10]1.[OH2:16].O[N:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26]C=2N=N1.Cl.CN(C)CCCN=C=NCC>CC(N(C)C)=O>[C:6]([N:18]1[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1)([O:5][C:9]([CH3:14])([CH3:10])[CH3:8])=[O:16]

Komponenten

6

Edukt 4

HCID 79724-MethylmorpholineHCID 1182593,5-DimethylpiperidineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27960291-Hydroxybenzotriazole hydrate

Produkt 1

HCID 7010304N-(tert-butoxycarbonyl)piperidineAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel

Versuchsvorschrift

Part A: To a solution of N-BOC-isoponic acid (4.0 g, 17.4 mmol) in dimethylacetamide (30 mL) were added N-methylmorpholine (Aldrich. 5.7 mL, 52.2 mmol), 3,5-dimethylpiperadine (70% cis. Aldrich, 3.5 mL, 26.1 mmol). N-hydroxybenzotriazole hydrate (Aldrich, 2.8 g, 20.9 mmol), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (Sigma, 5.0 g, 26.1 mmol). The mixture was stirred overnight (about 18 hours) at ambient temperature. To work up, the solvent was removed and the residue was taken up in ethyl acetate (300 mL) then washed with 5% KHSO4 aq (1×100 ml), saturated K2CO3 aq (1×100 mL), and brine (1×100 mL). After drying over Na2SO4, the organic layer was filtered and concentrated to afford the BOC-piperidine as a tan oil that slowly crystallized (5.4 g, 96% yield). 1H NMR showed the desired compound existing as both the cis- and trans-isomers.

Aufarbeitung

  1. customthe solvent was removed
  2. washthen washed with 5% KHSO4 aq (1×100 ml), saturated K2CO3 aq (1×100 mL), and brine (1×100 mL)
  3. dry with materialAfter drying over Na2SO4
  4. filtrationthe organic layer was filtered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-b52f67d44f3147abb12af4f37d7ce260
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06800646B1

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