Bromocyclopropane → Butyl-[1-(2-cyclopropyl-4,6-bis-trifluoromethyl-phenyl)-methylidene]-amine

HRID 39428

Reaktionsgleichung

Reaktionsgleichung von HRID 39428
[CH:1]1(Br)[CH2:3][CH2:2]1.[Mg].[CH2:6]([N:10]=[CH:11][C:12]1[C:17]([C:18]([F:21])([F:20])[F:19])=[CH:16][C:15]([C:22]([F:25])([F:24])[F:23])=[CH:14][C:13]=1F)[CH2:7][CH2:8][CH3:9]>C(OCC)C.[Cl-].[Mn+2].[Cl-]>[CH2:6]([N:10]=[CH:11][C:12]1[C:17]([C:18]([F:21])([F:20])[F:19])=[CH:16][C:15]([C:22]([F:25])([F:24])[F:23])=[CH:14][C:13]=1[CH:1]1[CH2:3][CH2:2]1)[CH2:7][CH2:8][CH3:9]

Komponenten

6

Edukt 3

HCID 78037BromocyclopropaneHCID 5462224MagnesiumHCID 58167770Butyl-[1-(2-fluoro-4,6-bis-trifluoromethyl-phenyl)-methylidene]-amine2×

Produkt 1

HCID 58167766Butyl-[1-(2-cyclopropyl-4,6-bis-trifluoromethyl-phenyl)-methylidene]-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 10313134Manganese(2+) dichlorideKatalysatorHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

Cyclopropylbromide (3.84 g, 32 mmol) was added to magnesium (771 mg, 32 mmol) in 20 mL diethylether and refluxed for 10 min. Manganese(II) chloride (160 mg, 1.27 mmol) and butyl-[1-(2-fluoro-4,6-bis-trifluoromethyl-phenyl)-methylidene]-amine (intermediate M, 4 g, 13 mmol) was added. The reaction mixture was refluxed for 2 h. The reaction mixture was quenched with 8 mL water and filtered through dicalite. The organic phase was separated and dried on sodium sulfate, filtered and evaporated. The crude material, brown oil (3.54 g, 82%) was used without further purification.

Aufarbeitung

  1. temperaturerefluxed for 10 min
  2. temperatureThe reaction mixture was refluxed for 2 h
  3. customThe reaction mixture was quenched with 8 mL water
  4. filtrationfiltered through dicalite
  5. customThe organic phase was separated
  6. customdried on sodium sulfate
  7. filtrationfiltered
  8. customevaporated
  9. customThe crude material, brown oil (3.54 g, 82%) was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-98c6ae645cf442be9c235d2382fa39de
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524909B2

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