Hydrogen Peroxide → 3-Fluoroisonicotinic acid 1-oxide

HRID 39508

Reaktionsgleichung

Reaktionsgleichung von HRID 39508
[F:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH:11]O>C(O)(=O)C>[F:1][C:2]1[CH:10]=[N+:9]([O-:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

4

Edukt 2

HCID 784Hydrogen PeroxideHCID 3453613-Fluoropyridine-4-carboxylic acid

Produkt 1

HCID 576496373-Fluoroisonicotinic acid 1-oxide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

To a solution of 3-fluoroisonicotinic acid (5.0 g, 35.33 mmol) in acetic acid (25 ml) was added hydrogen peroxide (6 ml). The reaction mixture was stirred at 70-80° C. overnight. The solvent was removed to obtain 5.5 g of 3-fluoroisonicotinic acid 1-oxide in quantitative yield.

Aufarbeitung

  1. customThe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-eefb4f777a6c4d60abf2477d1e1f9e78
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524911B2

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