Acetic Acid → HCID 23445018, Verbindung

HRID 397930

Reaktionsgleichung

Reaktionsgleichung von HRID 397930
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1)[NH2:5].[CH:13](OCC)(OCC)OCC.[N+:23]([CH2:26]C(OCC)=O)([O-])=O.[C:32]([OH:35])(=[O:34])[CH3:33]>[Fe]>[F:1][C:2]1[CH:3]=[C:4]([N:5]2[CH:13]=[C:33]([C:32]([OH:35])=[O:34])[N:23]=[CH:26]2)[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

Komponenten

6

Edukt 4

HCID 176Acetic Acid2×HCID 31214Ethyl orthoformate2×HCID 69379Ethyl nitroacetateHCID 27359133-Amino-5-fluorobenzotrifluoride

Produkt 1

HCID 23445018HCID 23445018, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23925IronKatalysator

Versuchsvorschrift

Following the general method described in example 234, 3-fluoro-5-trifluoromethylaniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The title compound was obtained as a white crystalline solid. Mp.>250° C. (H2O/dioxane), MS: m/e=273 (M−H−).

Quellen und Nachweise

ORD-Eintrag
ord-b147aa1cff6e43aeaab32b572cddd72d
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06610723B2

Verknüpfte Notizen

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