2,4-Di-tert-butylphenol → 2-Bromo-4,6-di-tert-butylphenol

HRID 398068Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 398068
[C:1]([C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:8]=[CH:7][C:6]=1[OH:15])([CH3:4])([CH3:3])[CH3:2].[Br:16]Br>CC(O)=O>[Br:16][C:7]1[CH:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:6]=1[OH:15]

Komponenten

4

Edukt 2

HCID 73112,4-Di-tert-butylphenolHCID 24408Bromine

Produkt 1

HCID 5198222-Bromo-4,6-di-tert-butylphenolAusbeute 91,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution of 2,4-di-t-butylphenol (Aldrich, 2.0 g, 9.7 mmol) in 2 ml of HOAc was added Br2 (0.5 ml, 9.7 mmol). The reaction mixture was stirred at room temperature for 12 hours. Solvent was removed under reduced pressure and the residue was purified by column chromatography (ethyl acetate/hexane 1/20) to yield the desired product (2.54 g) as a white solid. 1H NMR δ7.33 (d, J=2.3 Hz, 1H), 7.24 (d, J=2.3 Hz, 1H), 1.41 (s, 9H), 1.29 (s, 9H).

Aufarbeitung

  1. customSolvent was removed under reduced pressure
  2. customthe residue was purified by column chromatography (ethyl acetate/hexane 1/20)

Quellen und Nachweise

ORD-Eintrag
ord-e9321be272664a6289d41b9f2ad2a541
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06610744B2

Notizen zur Reaktion

Wird geladen…