2-Chloro-1-fluoro-4-nitrobenzene → 2-chloro-1-(methylsulfanyl)-4-nitrobenzene

HRID 398086

Reaktionsgleichung

Reaktionsgleichung von HRID 398086
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[Cl:11].[CH3:12][S-:13].[Na+]>CN(C=O)C.C(C1C(O)=CC(C)=C(SC2C=C(C(C)(C)C)C(O)=CC=2C)C=1)(C)(C)C>[Cl:11][C:3]1[CH:4]=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=1[S:13][CH3:12]

Komponenten

5

Edukt 2

HCID 676882-Chloro-1-fluoro-4-nitrobenzeneHCID 4378561Sodium methanethiolate

Produkt 1

HCID 105600942-chloro-1-(methylsulfanyl)-4-nitrobenzeneAusbeute 52,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 7308SantonoxKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 4-fluoro-3-chloronitrobenzene (27 g, 156 mmol) in DMF (150 mL) at room temperature was added 5-tert-butyl-4-hydroxy-2-methylphenyl sulfide (100 mg) followed by sodium thiomethoxide (NaSMe) (10 g, 143 mmol) and the reaction was stirred for 6 h. The DMF was removed in vacuo and the residue was partitioned between ether (1 L) and water (1 L). The ether layer was washed with water (1 L) and brine (1 L), dried (MgSO4) and the solvent was removed under reduced pressure. The residue was purified by column chromatography (SiO2; DCM: pentane 1:5 increasing polarity to 3:7) to give the title compound (15.22 g, 49%) as a yellow solid; δH (400 MHz, CDCl3) 2.53 (3H, s), 7.20 (1H, d), 8.09 (1H, dd), 8.20 (1H, d).

Aufarbeitung

  1. customThe DMF was removed in vacuo
  2. customthe residue was partitioned between ether (1 L) and water (1 L)
  3. washThe ether layer was washed with water (1 L) and brine (1 L)
  4. dry with materialdried (MgSO4)
  5. customthe solvent was removed under reduced pressure
  6. customThe residue was purified by column chromatography (SiO2; DCM: pentane 1:5 increasing polarity to 3:7)

Quellen und Nachweise

ORD-Eintrag
ord-76eb74a912a34d528fe9645b42d50541
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06610747B2

Verknüpfte Notizen

Wird geladen…