Water → 3-(4-Aminophenyl)propionic acid

HRID 399549

Reaktionsgleichung

Reaktionsgleichung von HRID 399549
O.[N+:2]([C:5]1[CH:15]=[CH:14][C:8]([CH:9]=[CH:10][C:11]([OH:13])=[O:12])=[CH:7][CH:6]=1)([O-])=O.[H][H]>[Pd].CO>[NH2:2][C:5]1[CH:6]=[CH:7][C:8]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:14][CH:15]=1

Komponenten

6

Edukt 3

HCID 962WaterHCID 701562-Propenoic acid, 3-(4-nitrophenyl)-HCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 754513-(4-Aminophenyl)propionic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

15 g of palladium on carbon (10% and 30 ml of water are added to a mixture of 155 g of 4-nitrocinnamic acid in 1 l of methanol, and hydrogenation is carried out at room temperature under 3 bar until no further hydrogen is taken up, after about 2 hours. After filtration and evaporation of the solvent in a rotary evaporator, residual water is removed by twice adding 300 ml portions of toluene and distilling off the solvent in a rotary evaporator.

Aufarbeitung

  1. filtrationAfter filtration and evaporation of the solvent
  2. customin a rotary evaporator, residual water
  3. customis removed
  4. additionby twice adding 300 ml portions of toluene
  5. distillationdistilling off the solvent
  6. customin a rotary evaporator

Quellen und Nachweise

ORD-Eintrag
ord-080107e432b24871a28213b866e90934
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05821240

Verknüpfte Notizen

Wird geladen…