Acetic Anhydride → 1-Benzyl-3-(3-chlorophenyl)-1-(cyanoacetyl)urea

HRID 399590

Reaktionsgleichung

Reaktionsgleichung von HRID 399590
[CH2:1]([NH:8][C:9]([NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19]([CH2:21][C:22](O)=[O:23])#[N:20].C(OC(=O)C)(=O)C>CCOCC>[CH2:1]([N:8]([C:22](=[O:23])[CH2:21][C:19]#[N:20])[C:9]([NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 7918Acetic AnhydrideHCID 9740Cyanoacetic acidHCID 5813901-Benzyl-3-(3-chlorophenyl)urea

Produkt 1

HCID 28228541-Benzyl-3-(3-chlorophenyl)-1-(cyanoacetyl)urea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A mixture of 1-benzyl-3-(3-chlorophenyl)urea (44.78 g) and cyanoacetic acid (16.11 g) was ground together and then acetic anhydride (48 ml) added. The resulting mixture was heated and stirred at 75°-80° C. for 16 h. It was then allowed to cool, diluted with ether and the product filtered off and washed with ether. This was then recrystallised from toluene with a hot filtration. Yield=20.15 g.

Aufarbeitung

  1. temperatureThe resulting mixture was heated
  2. temperatureto cool
  3. filtrationthe product filtered off
  4. washwashed with ether
  5. customThis was then recrystallised from toluene with a hot filtration

Quellen und Nachweise

ORD-Eintrag
ord-14d924b3ea464728bb4f78179e52d8d6
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05821366

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