Dimethylformamide → Methyl 3-(2-carbamoylpyrrol-1-yl)benzoate

HRID 399819Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 399819
[NH4+].[OH-].ClC(Cl)(Cl)[C:5]([C:7]1[N:8]([C:12]2[CH:13]=[C:14]([CH:19]=[CH:20][CH:21]=2)[C:15]([O:17][CH3:18])=[O:16])[CH:9]=[CH:10][CH:11]=1)=[O:6].C[N:25](C)C=O.C(OCC)(=O)C>O>[C:5]([C:7]1[N:8]([C:12]2[CH:13]=[C:14]([CH:19]=[CH:20][CH:21]=2)[C:15]([O:17][CH3:18])=[O:16])[CH:9]=[CH:10][CH:11]=1)(=[O:6])[NH2:25]

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 14923Ammonium HydroxideHCID 18945198Methyl 3-(2-trichloroacetylpyrrol-1-yl)benzoate

Produkt 1

HCID 18945445Methyl 3-(2-carbamoylpyrrol-1-yl)benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

28% Ammonia aqueous solution (0.4 ml) was added to a mixture of methyl 3-(2-trichloroacetylpyrrol-1-yl)benzoate (1.0 g) and N,N-dimethylformamide (2 ml), and the mixture was stirred for 1.5 hours at ambient temperature. The mixture was poured into a mixture of ethyl acetate and water. The separated organic layer was washed with water, dried over magnesium sulfate and evaporated in vacuo. The residue was triturated with diisopropyl ether to give methyl 3-(2-carbamoylpyrrol-1-yl)benzoate (0.61 g).

Aufarbeitung

  1. washThe separated organic layer was washed with water
  2. dry with materialdried over magnesium sulfate
  3. customevaporated in vacuo
  4. customThe residue was triturated with diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-c7cb23aa2e8f47fd8db795ff3d1f02f4
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05824691

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