Dibutylamine → N,N-Dibutyl-3-oxobutanamide

HRID 400204Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 400204
[C:1]([O:7]CC)(=O)[CH2:2][C:3]([CH3:5])=[O:4].[CH2:10]([NH:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:11][CH2:12][CH3:13]>C(OCC)C>[CH2:10]([N:14]([CH2:15][CH2:16][CH2:17][CH3:18])[C:1](=[O:7])[CH2:2][C:3](=[O:4])[CH3:5])[CH2:11][CH2:12][CH3:13]

Komponenten

4

Edukt 2

HCID 8148DibutylamineHCID 8868Ethyl Acetoacetate

Produkt 1

HCID 243714N,N-Dibutyl-3-oxobutanamideAusbeute 67,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

A! A mixture of ethyl acetoacetate (50 g, 0.38 mole) and dibutylamine (49.65 g, 0.38 mole) was heated to 150° C. for one day. After cooling, the reaction mixture was taken up in 500 ml of ethyl ether and washed with 200 ml of 1N HCl and 200 ml of water. The ether phase was anhydrified over sodium sulfate, and evaporated to dryness thus yielding 86.7 g of a crude which was distilled under vacuum to give 54.86 g (yield: 67%) of N,N-dibutyl-3-oxo-butanamide.

Aufarbeitung

  1. temperatureAfter cooling
  2. washwashed with 200 ml of 1N HCl and 200 ml of water
  3. customevaporated to dryness
  4. customthus yielding 86.7 g of a crude which
  5. distillationwas distilled under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-43ba1776ad0d4475bd7f9e0bb00232af
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05827881

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