4-Chlorobenzoyl chloride → (S)-Methyl 2-(6-(4-(4-chlorobenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

HRID 403785

Reaktionsgleichung

Reaktionsgleichung von HRID 403785
[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][N:21]([C@@H:26]([CH:31]([CH3:33])[CH3:32])[C:27]([O:29][CH3:30])=[O:28])[C:22]3=[O:25])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1.[Cl:59]C1C=CC(C(Cl)=O)=CC=1>>[Cl:59][C:5]1[CH:4]=[CH:3][C:2]([C:1]([NH:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:24]=[C:23]4[C:19]([CH2:20][N:21]([C@@H:26]([CH:31]([CH3:33])[CH3:32])[C:27]([O:29][CH3:30])=[O:28])[C:22]4=[O:25])=[CH:18][CH:17]=3)=[CH:14][CH:15]=2)=[O:8])=[CH:7][CH:6]=1

Komponenten

4

Edukt 3

HCID 85014-Chlorobenzoyl chlorideHCID 123625862(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Produkt 1

HCID 53303633(S)-Methyl 2-(6-(4-(4-chlorobenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Versuchsvorschrift

The compound of example 113 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 4-chlorobenzoyl chloride. The compound of example 113 was used directly without isolation for the preparation of compound of example 114.

Quellen und Nachweise

ORD-Eintrag
ord-a69cb6dc75c147a1bb67389bbb58db09
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08748426B2

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