Morpholine → Methyl 5-bromo-2-morpholinobenzoate

Temperatur

100 °C

To a solution of methyl 5-bromo-2-iodobenzoate (2.1 g, 6.16 mmol) in DME (15 mL) were morpholine (0.593 mL, 6.78 mmol), rac-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl (0.384 g, 0.62 mmol), Palladium acetate (0.138 g, 0.62 mmol) and CESIUM CARBONATE (2.81 g, 8.62 mmol) added. The mixture was heated in the microwave oven for 1h. The solvent was evaporated and the crude product was added to a silica gel column, 0-25% EtOAc in heptane yielding [Products]

ORD-Eintrag

ord-b45fc3e4fad4439cafccda47ed5c0991

Quelldatensatz

750 AstraZeneca ELN dataset

Originallink

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