Acetic Acid → 4-Amino-2-fluorobenzoic acid

HRID 407285

Reaktionsgleichung

Reaktionsgleichung von HRID 407285
[F:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C(O)(=O)C>[Pd].CO>[NH2:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[CH:10]=1

Komponenten

5

Edukt 2

HCID 176Acetic AcidHCID 3026792-Fluoro-4-nitrobenzoic acid

Produkt 1

HCID 3026804-Amino-2-fluorobenzoic acidAusbeute 102,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-fluoro-4-nitrobenzoic acid (1.0 g, 5.4 mmol) in 20 mL of a mixture of acetic acid and methanol (1:1), was added a catalytic amount of palladium on charcoal (25 mg). The reaction was stirred under an atmosphere of hydrogen gas at room temperature overnight. The mixture was then filtered through celite and the solvent was removed by evaporation to yield 0.86 g (100%) of the title compound as a cream coloured solid.

Aufarbeitung

  1. filtrationThe mixture was then filtered through celite
  2. customthe solvent was removed by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-f70d0418ffcb4c2ca79700e34c3bd20b
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08754233B2

Verknüpfte Notizen

Wird geladen…