Water → HCID 178503598, Verbindung

HRID 407302

Reaktionsgleichung

Reaktionsgleichung von HRID 407302
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10](=[C:13](SC)[S:14][CH3:15])[C:11]#[N:12].O.[NH2:19][NH2:20].O>C(O)C>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:11]([NH2:12])=[N:19][NH:20][C:13]=1[S:14][CH3:15]

Komponenten

5

Edukt 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 28077272-Benzothiazol-2-yl-3,3-bis-methylsulfanylacrylonitrile

Produkt 1

HCID 178503598HCID 178503598, VerbindungAusbeute 44 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a suspension of 2-benzothiazol-2-yl-3,3-bismethylsulfanylacrylonitrile (50 mg, 0.18 mmol) in ethanol (2 mL) was added hydrazine hydrate (15 μL). The mixture was heated to reflux for 2 hours. The reaction mixture was then cooled and water was added. The resulting precipitate was isolated by filtration to yield 21 mg (44%) of the title compound as a yellow solid. MS (m/z, ES+): 263 (M+1, 100%).

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 2 hours
  3. temperatureThe reaction mixture was then cooled
  4. customThe resulting precipitate was isolated by filtration

Quellen und Nachweise

ORD-Eintrag
ord-dbd6832e695e455380cc1a0e31d9d7d2
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08754233B2

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