(S)-1-(1-(5-bromopyrimidin-2-yl)piperidin-4-yl)-3-(2,5-difluoro-4-(methylsulfonyl)phenoxy)pyrrolidin-2-one → (S)-3-(2,5-difluoro-4-(methylsulfonyl)phenoxy)-1-(1-(5-(pyridin-2-yl)pyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one
Reaktionsgleichung
[Br-].[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[Zn+].Br[C:10]1[CH:11]=[N:12][C:13]([N:16]2[CH2:21][CH2:20][CH:19]([N:22]3[CH2:26][CH2:25][C@H:24]([O:27][C:28]4[CH:33]=[C:32]([F:34])[C:31]([S:35]([CH3:38])(=[O:37])=[O:36])=[CH:30][C:29]=4[F:39])[C:23]3=[O:40])[CH2:18][CH2:17]2)=[N:14][CH:15]=1>C1COCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Zn].[Pd]>[F:39][C:29]1[CH:30]=[C:31]([S:35]([CH3:38])(=[O:37])=[O:36])[C:32]([F:34])=[CH:33][C:28]=1[O:27][C@H:24]1[CH2:25][CH2:26][N:22]([CH:19]2[CH2:20][CH2:21][N:16]([C:13]3[N:12]=[CH:11][C:10]([C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][N:2]=4)=[CH:15][N:14]=3)[CH2:17][CH2:18]2)[C:23]1=[O:40]Komponenten
7
