Acetaldehyde → 1-[6-Chloro-5-ethylamino-1-(2-methoxy-ethoxymethyl)-1H-benzoimidazol-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester

Temperatur

23 °C

To a slurry of 4 Å molecular sieves (1.2 g) and 1-[5-amino-6-chloro-1-(2-methoxy-ethoxymethyl)-1H-benzoimidazol-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Intermediate from Example 41, product from Step A) (0.300 g, 0.762 mmol), and ethanol (3 mL) was added acetaldehyde (0.500 mL, 8.91 mmol) at 0° C. in a sealable microwave tube. The tube was sealed and the reaction mixture was allowed to warm to 23° C. over 16 h. The reaction mixture was heated at 60° C. for 1 h. The molecular sieves were removed from the resulting solution by filtration and the filtrate was concentrated under reduced pressure. Sodium triacetoxy borohydride (0.242 g, 1.14 mmol), THF (3 mL), and glacial acetic acid (0.04 mL) were added to the residue and the resulting suspension was stirred for 7.5 h at 23° C. The reaction mixture was concentrated and the residue partitioned between saturated aqueous sodium bicarbonate and EtOAc (35 mL). The aqueous layer was further extracted with EtOAc (2×35 mL) and the combined organic layers were washed with brine (15 mL), dried, filtered, and concentrated under reduced pressure. The residue was purified (FCC) (10-45% EtOAc/hexanes) to yield the titled compound (0.169 g, 47% crude yield). This compound was used without further purification in subsequent reactions. MS (ESI/CI): mass calcd. for C19H24ClN5O4, 421.2; m/z found, 422.1 [M+H]+.

1. customThe tube was sealed
2. temperatureThe reaction mixture was heated at 60° C. for 1 h
3. customThe molecular sieves were removed from the resulting solution by filtration
4. concentrationthe filtrate was concentrated under reduced pressure
5. concentrationThe reaction mixture was concentrated
6. customthe residue partitioned between saturated aqueous sodium bicarbonate and EtOAc (35 mL)
7. extractionThe aqueous layer was further extracted with EtOAc (2×35 mL)
8. washthe combined organic layers were washed with brine (15 mL)
9. customdried
10. filtrationfiltered
11. concentrationconcentrated under reduced pressure
12. customThe residue was purified (FCC) (10-45% EtOAc/hexanes)

ORD-Eintrag

ord-257750485b07401298b836b184ab3782

Quelldatensatz

uspto-grants-2014_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08759345B2