Lithium hydroxide, monohydrate → 2-(4-Iodophenyl)propanoic acid

HRID 409716

Reaktionsgleichung

Reaktionsgleichung von HRID 409716
O.[OH-].[Li+].C[O:5][C:6](=[O:16])[CH:7]([C:9]1[CH:14]=[CH:13][C:12]([I:15])=[CH:11][CH:10]=1)[CH3:8]>O.C1COCC1.CO>[I:15][C:12]1[CH:11]=[CH:10][C:9]([CH:7]([CH3:8])[C:6]([OH:16])=[O:5])=[CH:14][CH:13]=1

Komponenten

6

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 10589545Methyl 2-(4-iodophenyl)propanoate

Produkt 1

HCID 152255732-(4-Iodophenyl)propanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

0.610 g (14.6 mmol) Lithiumhydroxide monohydrate in 15 mL water are added to 2.12 g (7.31 mmol) 2-(4-iodo-phenyl)-propionic acid methyl ester (Bioorg. Med. Chem. Lett. 2010, 20, 896) in 20 mL THF and 12 mL MeOH at 0° C. Cooling is removed and the mixture is stirred at rt for 2 h. After that time, the mixture is acidified with 1 N HCl to pH˜1 and extracted with DCM. The organic layer is washed with brine, dried over sodium sulphate and the solvent is evaporated. The product is used without further purification in Example IV.1.

Aufarbeitung

  1. temperatureCooling
  2. customis removed
  3. extractionextracted with DCM
  4. washThe organic layer is washed with brine
  5. dry with materialdried over sodium sulphate
  6. customthe solvent is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-c2a403cc04d34e08a6473cf5b7c8264e
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759528B2

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