Water → HCID 59625812, Verbindung

HRID 409930Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 409930
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)[C:5]([O:7][CH3:8])=[O:6].[CH:20](OC)(OC)OC.O>CN(C=O)C>[F:19][C:16]1[CH:17]=[CH:18][C:13]([N:12]2[C:11]3[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=3[N:1]=[CH:20]2)=[CH:14][CH:15]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 9005Trimethyl orthoformateHCID 59625705HCID 59625705, Verbindung

Produkt 1

HCID 59625812HCID 59625812, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 27d (0.18 g, 0.693 mmol) and trimethyl orthoformate (0.7 mL, 6.39 mmol) in DMF (2 mL) was refluxed for 5 h and then cooled to room temperature. Water was added to the mixture. The resulting solid was filtered, washed, with water, and dried. The crude product 27e was used in the next reaction without purification. MS m/z (M+H+) 271.1.

Aufarbeitung

  1. temperaturewas refluxed for 5 h
  2. filtrationThe resulting solid was filtered
  3. washwashed, with water
  4. customdried
  5. customThe crude product 27e was used in the next reaction without purification

Quellen und Nachweise

ORD-Eintrag
ord-e0b80af3d8b3457b9b9e24255fea7b1f
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759533B2

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