3-Amino-1-propanol → 4-((3-Hydroxypropyl)amino)benzonitrile

HRID 411135Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 411135
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[NH2:10][CH2:11][CH2:12][CH2:13][OH:14]>O>[OH:14][CH2:13][CH2:12][CH2:11][NH:10][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 90863-Amino-1-propanolHCID 145174-Fluorobenzonitrile

Produkt 1

HCID 218676634-((3-Hydroxypropyl)amino)benzonitrileAusbeute 97,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 4-fluorobenzonitrile (12.0 g, 99.1 mmol) and 3-amino-1-propanol (59.6 g, 793 mmol) was stirred at 80° C. under an inert atmosphere for 3 hours before water (150 mL) was added. The mixture was allowed to cool to rt, and was then extracted with diethyl ether. The organic layer was separated, dried (Na2SO4), filtered and concentrated in vacuo to yield 17 g (97%) of the title compound as an oil that crystallised upon standing.

Aufarbeitung

  1. additionwas added
  2. extractionwas then extracted with diethyl ether
  3. customThe organic layer was separated
  4. dry with materialdried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1e97ef9354af4d1680bfd88b12d01559
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06559143B1

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