Water → Furan-2-acetic acid

HRID 413464

Reaktionsgleichung

Reaktionsgleichung von HRID 413464
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]#N.[OH-:9].[K+].[OH2:11]>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([OH:11])=[O:9]

Komponenten

4

Edukt 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 109095152-Furanacetonitrile

Produkt 1

HCID 75974Furan-2-acetic acid

Versuchsvorschrift

A mixture of 2-furanacetonitrile (6.14 g), KOH (4.0 g), and water (25 mL) was refluxed for 1 hour and then cooled. Following extraction with ether, the aqueous layer was acidified to pH 2.0 with concentrated aqueous HCl. This solution was extracted with ether, and the organic phase was dried over MgSO4 and evaporated under vacuum to yield 2-furanacetic acid. The structure of the product was confirmed by NMR.

Aufarbeitung

  1. temperaturewas refluxed for 1 hour
  2. temperaturecooled
  3. extractionextraction with ether
  4. extractionThis solution was extracted with ether
  5. dry with materialthe organic phase was dried over MgSO4
  6. customevaporated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-dc1b7ed696e7453f8c2cfc7d65c6a3d5
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06566508B2

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