Bromoacetic Acid → HCID 178418509, Verbindung

HRID 4163

Reaktionsgleichung

Reaktionsgleichung von HRID 4163
[SH:1][C:2]1[S:3][C:4]([SH:7])=[N:5][N:6]=1.[OH-].[K+].Br[CH2:11][C:12]([OH:14])=[O:13]>O>[C:12]([CH2:11][S:1][C:2]1[S:3][C:4]([SH:7])=[N:5][N:6]=1)([OH:14])=[O:13]

Komponenten

5

Edukt 3

HCID 6227Bromoacetic AcidHCID 14797Potassium HydroxideHCID 178418558HCID 178418558, Verbindung

Produkt 1

HCID 178418509HCID 178418509, VerbindungAusbeute 86,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

In 200 ml of water were dissolved 15.0 g of 2,5-dimercapto-1,3,4-thiadiazole and 69 g of potassium hydroxide, and a solution of 13.9 g of bromoacetic acid in 30 ml of water was added thereto dropwise at room temperature. After the addition, the mixture was stirred at 60° C. for 1 hour, followed by allowing to cool to room temperature. The precipitated crystals were filtered and washed with water to obtain 18 g of the desired compound. Melting point: 161°-167° C.

Aufarbeitung

  1. customdropwise at room temperature
  2. additionAfter the addition
  3. temperatureto cool to room temperature
  4. filtrationThe precipitated crystals were filtered
  5. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-03c19910184945d28d0037efcffa7194
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04724199

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