Water → 2-Methoxy-6-methylpyridin-3-ol

HRID 416555

Reaktionsgleichung

Reaktionsgleichung von HRID 416555
Cl[C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][O-:11].[Na+].CO.O>C(O)(=O)C>[CH3:10][O:11][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([CH3:9])[N:3]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 30157972-Chloro-6-methylpyridin-3-olHCID 23694274Sodium methanolate methanol

Produkt 1

HCID 234638212-Methoxy-6-methylpyridin-3-olAusbeute 48,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

In metal sealed tube were added 2-chloro-3-hyroxy-6-methylpyridine (1-014-02) (22.91 g) and 28% sodium methoxide/methanol solution (120 mL) and the reaction mixture was reacted at 150° C. for 3 days. To the reaction mixture was added ice and water (100 mL) and the reaction mixture was neutralized with acetic acid, and evaporated completely. The residue was purified by silica gel column chromatography (chloroform) to give the desired 2-methoxy-3-hyroxy-6-methylpyridine (1-014-03) (10.44 g, 48.1%). Furthermore, the fraction contained the starting material was reacted in sealed tube again.

Aufarbeitung

  1. customIn metal sealed tube
  2. customthe reaction mixture was reacted at 150° C. for 3 days
  3. customevaporated completely
  4. customThe residue was purified by silica gel column chromatography (chloroform)

Quellen und Nachweise

ORD-Eintrag
ord-ef4cb71f106b46b9ad72c703118fd199
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08088924B2

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