Reaktionsgleichung
[CH2:1]([C:3]1([OH:13])[CH2:8][CH2:7][CH:6]([C:9]([F:12])([F:11])[F:10])[CH2:5][CH2:4]1)[CH3:2].C(N(CC)CC)C.[C:21](Cl)(=[O:25])[C:22]([CH3:24])=[CH2:23]>CN(C)C1C=CN=CC=1.CC(C)=O>[C:21]([O:13][C:3]1([CH2:1][CH3:2])[CH2:4][CH2:5][CH:6]([C:9]([F:10])([F:12])[F:11])[CH2:7][CH2:8]1)(=[O:25])[C:22]([CH3:24])=[CH2:23]Komponenten
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A four-necked flask equipped with a stirrer, a thermometer, and a dropping funnel was charged with 7.9 g (0.04 mol) of 1-ethyl-4-trifluoromethylcyclohexanol, 0.2 g of 4-dimethylaminopyridine, 4.9 g of triethylamine, and 20 g of acetone. The mixture was stirred to obtain a solution. A solution prepared by dissolving 4.6 g (0.044 mol) of methacrylic acid chloride in 5 g of acetone was added to the solution at 4° C. over 30 minutes. The mixture was stirred at 4° C. for 3 hours to obtain a reaction mixture. The reaction mixture was washed with water to obtain 8.0 g of 1-ethyl-4-(trifluoromethyl)cyclohexyl methacrylate (hereinafter may be referred to as “compound (M-3)” ((M-3) in Table 1)). The yield of 1-ethyl-4-(trifluoromethyl)cyclohexyl methacrylate with respect to 1-ethyl-4-trifluoromethylcyclohexanol was 76%.
Aufarbeitung
- customA four-necked flask equipped with a stirrer
- customto obtain a solution
- customA solution prepared
- additionwas added to the solution at 4° C. over 30 minutes
- stirringThe mixture was stirred at 4° C. for 3 hours
- customto obtain a reaction mixture
- washThe reaction mixture was washed with water
Quellen und Nachweise
- ORD-Eintrag
- ord-d932d86fdda44311868fb1815d018b40
- Quelldatensatz
- uspto-grants-2013_09
- Patentnummer
- US08535871B2
Verknüpfte Notizen
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