Sodium Carbonate → HCID 178513428, Verbindung

HRID 419692Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 419692
Cl.[NH2:2][OH:3].[C:4]([N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)#[N:5].C(=O)([O-])[O-].[Na+].[Na+]>O.CO>[OH:3][NH:2][C:4]([N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)=[NH:5]

Komponenten

6

Edukt 3

HCID 10340Sodium CarbonateHCID 73736PiperidinocarbonitrileHCID 443297Hydroxyamine hydrochloride

Produkt 1

HCID 178513428HCID 178513428, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

Amidine (e) is readily produced from nitrites. More specifically, hydroxylamine hydrochloride dissolved in a suitable solvent, such as water, is reacted with cyanopiperidine (g) in the presence of a base such as sodium carbonate in a suitable solvent, such as in methanol and exposed to heat to provide the hydroxycarbamimidoyl-piperidine (h). The hydroxycarbamimidoylpiperidine (h) in a suitable solvent, such as acetic acid, is then hydrogenated via palladium catalyst in the presence of acetic acid anhydride under pressure to provide amidine (e).

Aufarbeitung

  1. temperatureto heat

Quellen und Nachweise

ORD-Eintrag
ord-194efada7bc044ff9ce22b1cd19dc2a6
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093383B2

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