Phosphorus oxybromide → 2,3-Dibromo-5-nitropyridine
Reaktionsgleichung
[Br:1][C:2]1[C:3](O)=[N:4][CH:5]=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1.P(Br)(Br)([Br:14])=O.P(Br)(Br)Br>O>[Br:14][C:3]1[C:2]([Br:1])=[CH:7][C:6]([N+:8]([O-:10])=[O:9])=[CH:5][N:4]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 120 °C
Versuchsvorschrift
A mixture of 3-bromo-5-nitropyridin-2-ol, POBr3 and PBr3 was heated at 120° C. for 3.5 h. The crude mixture was poured into a mixture of ice and water and extracted with DCM. The crude mixture was purified by flash chromatography over SiO2 eluting with hexane/ethyl acetate mixtures affording 2.63 g (yield 73%) of the expected product.
Aufarbeitung
- extractionextracted with DCM
- customThe crude mixture was purified by flash chromatography over SiO2 eluting with hexane/ethyl acetate
Quellen und Nachweise
- ORD-Eintrag
- ord-a4e2c39a7efe46fa98d2f35b3345c17e
- Quelldatensatz
- uspto-grants-2013_09
- Patentnummer
- US08536165B2
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