Diisopropylethylamine → HCID 178513091, Verbindung

HRID 420206

Reaktionsgleichung

Reaktionsgleichung von HRID 420206
[C:1]1([S:7]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[CH:16]([CH2:20][C:21]([OH:23])=O)[CH2:15][CH2:14][CH2:13]3)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(C1NC=CN=1)(C1NC=CN=1)=O.S(O)(O)(=O)=O.[NH2:41][C:42]([NH2:44])=[NH:43].C(N(C(C)C)CC)(C)C>CN(C=O)C.O>[C:1]1([S:7]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[CH:16]([CH2:20][C:21]([NH:43][C:42]([NH2:44])=[NH:41])=[O:23])[CH2:15][CH2:14][CH2:13]3)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

7

Edukt 4

HCID 81531DiisopropylethylamineHCID 499987Guanidine Sulfate (1:1)HCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 66651343(6-Benzenesulfonyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetic acid

Produkt 1

HCID 178513091HCID 178513091, VerbindungAusbeute 89,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

(6-Benzenesulfonyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetic acid (0.30 grams, 0.80 mmole) and carbonyl diimidazole (0.13 gms, 0.90 mmole) in 30 mL DMF was stirred for three hours at room temperature. Guanidine sulfate (90 mg) was added, followed by 0.1 ml diisopropylethylamine, and the reaction mixture was stirred overnight. The reaction mixture was diluted with water, and the resulting white crystals were collected by filtration, washed with water, and dried under vacuum to afford 190 mg of N-[2-(6-Benzenesulfonyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetyl]-guanidine, M+H=372.

Aufarbeitung

  1. filtrationthe resulting white crystals were collected by filtration
  2. washwashed with water
  3. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-f33c1021d6734d1988225f2d7d8bebbe
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093424B2

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