Hydrochloric Acid → N-[2-[(Phenylmethyl)sulfonyl]ethyl]-2-propanamine hydrochloride

HRID 4207Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 4207
[Cl:1][CH2:2][CH2:3][S:4]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:6])=[O:5].[CH:14]([NH2:17])([CH3:16])[CH3:15].Cl.CCOCC>CO>[ClH:1].[C:8]1([CH2:7][S:4]([CH2:3][CH2:2][NH:17][CH:14]([CH3:16])[CH3:15])(=[O:6])=[O:5])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 6363IsopropylamineHCID 99230(((2-Chloroethyl)sulfonyl)methyl)benzene

Produkt 1

HCID 13655079N-[2-[(Phenylmethyl)sulfonyl]ethyl]-2-propanamine hydrochlorideAusbeute 65,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 51.49 g (0.236 mole) of benzyl 2-chloroethyl sulfone and 600 ml of isopropylamine was stirred at room temperature for 72 hr. The solvent was removed in vacuo, and the residue was partitioned between ether and dilute sodium hydroxide. The ether solution was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol, and excess ethereal hydrogen chloride was added. Ether was added, and a white solid precipitated to give 43.11 g (65.8%) of a white crystalline solid, m.p. 180.5°-181.5° C.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe residue was partitioned between ether and dilute sodium hydroxide
  3. dry with materialThe ether solution was dried over magnesium sulfate
  4. customthe solvent was removed in vacuo
  5. customto give an oil
  6. customa white solid precipitated

Quellen und Nachweise

ORD-Eintrag
ord-28031cec7bf3401286c156beffb1ffb3
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04724235

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