1H-Indole, 1-(1-methoxyethyl)- → [1-(1-methoxy-ethyl)-1H-indol-3-yl]-oxo-acetyl chloride
Reaktionsgleichung
[CH3:1][O:2][CH:3]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6]1)[CH3:4].[C:14](Cl)(=[O:18])[C:15]([Cl:17])=[O:16]>C(OCC)C>[CH3:1][O:2][CH:3]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14](=[O:18])[C:15]([Cl:17])=[O:16])=[CH:6]1)[CH3:4]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
To a solution of 1-(1-methoxyethyl)indole (4 gm, 23 mmol) (prepared as in step a) above) in anhydrous diethyl ether at 0° C. was added oxalyl chloride (4.2 mL, 48 mmol) over 5 minutes. The resulting slurry was stirred at 0° C. for 5 hours, and filtered to afford 1.9 gm of [1-(1-methoxy-ethyl)-1H-indol-3-yl]-oxo-acetyl chloride. (Yield 31%). The material was used without further purification.
Aufarbeitung
- filtrationfiltered
Quellen und Nachweise
- ORD-Eintrag
- ord-f31082a238384d90be116bd0f57a0ad4
- Quelldatensatz
- uspto-grants-2001_11
- Patentnummer
- US06313143B1
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