Acetic Acid → 7-Azaoxindole acetic acid salt

HRID 429100Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 429100
Br[C:2]1(Br)[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]1=[O:11].[C:13]([OH:16])(=[O:15])[CH3:14]>C(#N)C.[Zn]>[C:13]([OH:16])(=[O:15])[CH3:14].[NH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][N:6]=2)[CH2:2][C:3]1=[O:11]

Komponenten

5

Edukt 2

HCID 176Acetic AcidHCID 138640943,3-Dibromo-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

Produkt 1

HCID 219257347-Azaoxindole acetic acid saltAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23994ZincKatalysatorHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

3,3-Dibromo-7-azaoxindole (2.9 g) was dissolved in a mixture of 20 mL of acetic acid and 30 mL of acetonitrile. To the solution was added 6.5 g of zinc dust. The mixture was stirred A for 2 hrs at room temperature. The solid was filtered from the mixture and the solvent evaporated. The residue was slurried with ethyl acetate. The ethyl acetate solution containing insoluble solid was passed through a short column of silica gel. The collected ethyl acetate solution was evaporated and the residue dried under vacuum to give 1.8 g (yield 91%) of 7-azaoxindole acetic acid salt.

Aufarbeitung

  1. filtrationThe solid was filtered from the mixture
  2. customthe solvent evaporated
  3. additionThe ethyl acetate solution containing insoluble solid
  4. customThe collected ethyl acetate solution was evaporated
  5. customthe residue dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-2bf55322531c4f688cd610b9e288b90d
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06316429B1

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