Water → 3-(Diethylboryl)pyridine

HRID 429382Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 429382
C([Li])CCC.Br[C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1.[CH2:13]([B:15]([CH2:18][CH3:19])OC)[CH3:14].O>C(OCCCC)CCC.[Cl-].[Na+].O>[CH2:13]([B:15]([CH2:18][CH3:19])[C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)[CH3:14]

Komponenten

7

Edukt 4

HCID 962WaterHCID 122863-BromopyridineHCID 522516DiethylmethoxyboraneHCID 178418339Butyllithium

Produkt 1

HCID 6428513-(Diethylboryl)pyridineAusbeute 76,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8909Butyl etherLösungsmittelHCID 57417360Sodium chloride; waterLösungsmittel

Versuchsvorschrift

Into a solution of n-butyl lithium (165 ml, 264 mmol) in butyl ether (250 ml) at −78 degrees under nitrogen was added 3-bromopyridine (25.4 ml, 264 mmol). After 1 h, added diethylmethoxyborane (52 ml, 396 mmol). The mixture was allowed to warm to room temperature. After 16 h, added water and brine, separated organic layer, dried over sodium sulfate, then concentrated. The resulting slurry was dissolved in isopropanol (500 ml), cooled and the product isolated by filtration give diethyl(3-pyridyl)borane (29.8 g).

Aufarbeitung

  1. waitAfter 16 h
  2. customseparated organic layer
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated
  5. dissolutionThe resulting slurry was dissolved in isopropanol (500 ml)
  6. temperaturecooled
  7. customthe product isolated by filtration

Quellen und Nachweise

ORD-Eintrag
ord-49831452b1514267bb7193666617d77f
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06316466B1

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