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Hydrochloric Acid → 4-[(Benzylamino)carbonyl]-3-methoxyphenylboronic acid

HRID 432262
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 432262
C([Li])CCC.[CH2:6]([NH:13][C:14](=[O:24])[C:15]1[CH:20]=[CH:19][C:18](Br)=[CH:17][C:16]=1[O:22][CH3:23])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[B:25](OC(C)C)([O:30]C(C)C)[O:26]C(C)C.Cl>O1CCCC1>[CH2:6]([NH:13][C:14]([C:15]1[CH:20]=[CH:19][C:18]([B:25]([OH:30])[OH:26])=[CH:17][C:16]=1[O:22][CH3:23])=[O:24])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 21531Triisopropyl borateHCID 22346886N-benzyl-4-bromo-2-methoxybenzamideHCID 178418339Butyllithium

Produkt 1

HCID 223467454-[(Benzylamino)carbonyl]-3-methoxyphenylboronic acidAusbeute 46 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028
Tetrahydrofuran
Lösungsmittel

Versuchsvorschrift

n-Butyl lithium(1.6 M in hexane solution, 8.0 ml, 12.88 mmol) was added slowly to a solution of N1-benzyl-4-bromo-2-methoxybenzamide (1.65 g, 5.15 mmol) in tetrahydrofuran (40 mL) at −78° C. After 30 minutes, triisopropyl borate (1.8 mL, 7.73 mmol) was added rapidly. The reaction mixture was allowed to warm up to room temperature after 13 minutes and stirred for 16 hours. Hydrochloric acid (2.5N, 36 mL) was added and the mixture was stirred overnight. Organic solvent was removed and the aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with brine, dried over MgSO4, filtered and concentrated. The residue was purified by flash column chromatography using dichloromethane/methanol (95:5) as mobile phase to give 4-[(benzylamino)carbonyl]-3-methoxyphenylboronic acid (0.675 g, 46%). 1H NMR (DMSO-d6) δ 3.90 (s, 3H), 4.51 (d, J=6.18 Hz, 2H), 7.24 (m, 1H), 7.34 (m, 4H), 7.43 (d, J=7.55 Hz, 1H), 7.59 (s, 1H), 7.69 (d, J=7.55 Hz, 1H), 8.23 (s, 2H), 8.69 (m, 1H).

Aufarbeitung

  1. stirringthe mixture was stirred overnight
  2. customOrganic solvent was removed
  3. extractionthe aqueous layer was extracted with ethyl acetate
  4. washThe combined organic layer was washed with brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customThe residue was purified by flash column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-53affb6e1e0e418c9736084538b816fc
Quelldatensatz
uspto-grants-2003_12
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US06660744B1

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