Water → 1-Iodo-4-methyl-4-nitro-pentane

HRID 432991Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 432991
CS(O[CH2:6][CH2:7][CH2:8][C:9]([CH3:14])([N+:11]([O-:13])=[O:12])[CH3:10])(=O)=O.[I-:15].[Na+].O>CC(C)=O>[CH3:10][C:9]([N+:11]([O-:13])=[O:12])([CH3:14])[CH2:8][CH2:7][CH2:6][I:15]

Komponenten

5

Edukt 3

HCID 962WaterHCID 5238Sodium IodideHCID 130471214-Methyl-4-nitropentyl methanesulfonate

Produkt 1

HCID 99430631-Iodo-4-methyl-4-nitro-pentaneAusbeute 99,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

4-Methyl-4-nitropentanol methanesulfonate (3.38 g, 15 mmol) was dissolved in acetone (50 ml) and sodium iodide (8.7 g, 58 mmol) was added. The mixture was stirred overnight. Water (20 ml) was added and acetone was evaporated by concentration under reduced pressure. The residue was extracted with ethyl acetate (50 ml). The extract was washed with 5% aqueous sodium thiosulfate solution (20 ml) and saturated brine (20 ml), and ethyl acetate was evaporated by concentration under reduced pressure to give the objective compound (3.84 g, yield 99.6%).

Aufarbeitung

  1. customacetone was evaporated by concentration under reduced pressure
  2. extractionThe residue was extracted with ethyl acetate (50 ml)
  3. washThe extract was washed with 5% aqueous sodium thiosulfate solution (20 ml) and saturated brine (20 ml), and ethyl acetate
  4. customwas evaporated by concentration under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-084abec90d204b638ecc24bdcab17c62
Quelldatensatz
uspto-grants-2003_12
Patentnummer
US06664412B2

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