Sodium borohydride → HCID 12223972, Verbindung

HRID 435709Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 435709
[CH3:1][N:2]([CH3:22])[S:3]([C:6]1[CH:21]=[CH:20][C:9]2[S:10][C:11]3[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=3[C:13](=[O:15])[CH2:14][C:8]=2[CH:7]=1)(=[O:5])=[O:4].[BH4-].[Na+]>O1CCOCC1.O>[CH3:1][N:2]([CH3:22])[S:3]([C:6]1[CH:21]=[CH:20][C:9]2[S:10][C:11]3[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=3[CH:13]([OH:15])[CH2:14][C:8]=2[CH:7]=1)(=[O:5])=[O:4]

Komponenten

5

Edukt 2

HCID 4311764Sodium borohydrideHCID 1222396710,11-Dihydro-2-dimethylsulphamoyl-dibenzo[b,f]-thiepin-10-one

Produkt 1

HCID 12223972HCID 12223972, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

14 g of 10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]-thiepin-10-one in 200 ml of dioxane are treated with 3.5 g of sodium borohydride in 15 ml of water and the mixture is stirred at 40° C for 4 hours. The mixture is evaporated under reduced pressure and the residue taken up in ethyl acetate and water. The organic phase is washed with water, dried and evaporated. 10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]-thiepin-10-ol is obtained.

Aufarbeitung

  1. customThe mixture is evaporated under reduced pressure
  2. washThe organic phase is washed with water
  3. customdried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-61da510d8fdc4f75b0d9bd1e94f92a3b
Quelldatensatz
uspto-grants-1977_02
Patentnummer
US04006144

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