Iodine chloride → 2-Aminomethyl-4-(1,1-dimethylpropyl)-6-iodophenyl hydrochloride
Reaktionsgleichung
[ClH:1].[NH2:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]([CH3:14])([CH3:13])[CH2:11][CH3:12])[CH:7]=[CH:6][C:5]=1O.[I:16]Cl>O.Cl>[NH2:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]([CH3:14])([CH3:13])[CH2:11][CH3:12])[CH:7]=[C:6]([I:16])[C:5]=1[Cl:1]Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- -10 °C
Versuchsvorschrift
2-Aminomethyl-4-(1,1-dimethylpropyl)phenol hydrochloride (4.6 g., 0.02 mole) is dissolved in water (15 ml.) and a solution of iodine monochloride (3.28 g.) in 3N hydrochloric acid (10 ml.) is added. The mixture is kept for 3 hours and then cooled to -10° C. The solid that separates is crystallized from ethanol- 12N hydrochloric acid (1:10) to obtain 2-aminomethyl-4-(1,1-dimethylpropyl)-6-iodophenyl hydrochloride (4.15 g.), m.p. 203°-204° C. (dec.).
Aufarbeitung
- customThe solid that separates is crystallized from ethanol- 12N hydrochloric acid (1:10)
Quellen und Nachweise
- ORD-Eintrag
- ord-bfeddec8dee04878bcd57887fa43a96b
- Quelldatensatz
- uspto-grants-1977_06
- Patentnummer
- US04029816
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