Bicarbonate Ion → Fluoromidine

HRID 437399

Reaktionsgleichung

Reaktionsgleichung von HRID 437399
CS(O[N:6]1[C:14]2[C:9](=[N:10][CH:11]=[C:12]([Cl:15])[CH:13]=2)[N:8]=[C:7]1[C:16]([F:19])([F:18])[F:17])(=O)=O.[I-].[Na+].CCOCC.C(=O)(O)[O-]>CC(C)=O>[Cl:15][C:12]1[CH:13]=[C:14]2[NH:6][C:7]([C:16]([F:17])([F:18])[F:19])=[N:8][C:9]2=[N:10][CH:11]=1

Komponenten

6

Edukt 4

HCID 769Bicarbonate IonHCID 3283Diethyl EtherHCID 5238Sodium IodideHCID 203599241-(METHYLSULFONYLOXY)-6-CHLORO-2-(TRIFLUOROMETHYL)-1H-IMIDAZO(4,5-b)PYRIDINE

Produkt 1

HCID 911208FluoromidineAusbeute 73 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel2×

Versuchsvorschrift

1-(Methylsulfonyloxy)-6-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine (20 milligrams) in 0.5 milliliter of acetone was treated with 0.1 gram of sodium iodide in 0.5 milliliter of acetone. The reaction mixture was shaken with ether and bicarbonate solution. The ether portion was dried over magnesium sulfate and evaporated, yielding 10 milligrams (about 73 percent) of 6-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine.

Aufarbeitung

  1. dry with materialThe ether portion was dried over magnesium sulfate
  2. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-fde4c1ece5ef45c68a2011d043d95a1d
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04031107

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