Acetic Acid → 1,3-dimethyl-1H-indazole-4,5-dicarboxylic acid

HRID 439726

Reaktionsgleichung

Reaktionsgleichung von HRID 439726
C(C1[C:11]([C:12](OCC)=[O:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5]([CH3:18])=[N:6][N:7]2[CH3:17])#N.Br.[C:20]([OH:23])(=[O:22])[CH3:21].[OH2:24]>>[CH3:17][N:7]1[C:8]2[C:4](=[C:21]([C:20]([OH:23])=[O:22])[C:11]([C:12]([OH:13])=[O:24])=[CH:10][CH:9]=2)[C:5]([CH3:18])=[N:6]1

Komponenten

5

Edukt 4

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 962WaterHCID 22402968ethyl 4-cyano-1,3-dimethyl-1H-indazole-5-carboxylate

Produkt 1

HCID 224029461,3-dimethyl-1H-indazole-4,5-dicarboxylic acidAusbeute 97,8 %

Versuchsvorschrift

A mixture of ethyl 4-cyano-1,3-dimethyl-1H-indazole-5-carboxylate (7.03 g, 28.7 mmol), concentrated hydrobromic acid (35 mL) and acetic acid (35 mL) is stirred for 2 hours at reflux temperature, cooled, diluted with water (200 mL) and stirred for 2 hours. Filtration of the reaction mixture affords the title product as a pale blue solid (6.57 g, 97.8%), mp 228.5°-232.5° C.

Aufarbeitung

  1. temperatureat reflux temperature
  2. temperaturecooled
  3. stirringstirred for 2 hours
  4. filtrationFiltration of the reaction mixture

Quellen und Nachweise

ORD-Eintrag
ord-417c8e0346a44ba482e9502310a2915f
Quelldatensatz
uspto-grants-1996_05
Patentnummer
US05516751

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