Water → 3-Iodo-4-methylbenzoic acid

HRID 44106

Reaktionsgleichung

Reaktionsgleichung von HRID 44106
C[O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[C:6]([I:11])[CH:5]=1.[OH-].[Na+].O>CO>[I:11][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[CH3:10])[C:3]([OH:12])=[O:2]

Komponenten

5

Edukt 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 13614033Methyl 3-iodo-4-methylbenzoate

Produkt 1

HCID 6216403-Iodo-4-methylbenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl-3-Iodo-4-methylbenzoate (3 g, 109 mmol, 1 eq) dissolved in MeOH (30 ml) was added sodium hydroxide (1.3 g, 327 mmol, 3 eq) followed by the addition of water (15 ml). The above solution was stirred at room temperature for 14 h. The solution was concentrated under vacuum, and then added water. The pH of the reaction was bought to 3 using Conc.HCl. The solid obtained was filtered and dried under vacuum. Yield: 2.7 g (96%). 1HNMR (400 MHz, DMSO-d6): δ 2.44 (s, 3H), 7.45 (d, J=8.00 Hz, 1H), 7.85 (d, J=3.18 Hz, 1H), 8.31 (s, 1H).

Aufarbeitung

  1. concentrationThe solution was concentrated under vacuum
  2. customThe solid obtained
  3. filtrationwas filtered
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-4e88ff1604a94ca7b5dd632420ca3b1e
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536338B2

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