Acetic Acid → Ethyl (2-acetamido-3-benzoylphenyl)acetate

HRID 442533Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 442533
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[CH:8][CH:7]=[CH:6][C:5]=2[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19].C(O)(=[O:25])C.O=[O+][O-].[OH2:30]>>[C:2]([NH:3][C:4]1[C:9]([C:10](=[O:25])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])(=[O:30])[CH3:1]

Komponenten

5

Edukt 4

HCID 176Acetic Acid2×HCID 962WaterHCID 24823OzoneHCID 23342680Ethyl (2-methyl-3-phenyl-1H-indol-7-yl)acetate

Produkt 1

HCID 54304647Ethyl (2-acetamido-3-benzoylphenyl)acetate

Versuchsvorschrift

A solution of 5 g. (0.017 mole) of ethyl α-(2-methyl-3-phenylindol-7yl)acetate and 75 ml. of acetic acid was treated with ozone for 25 minutes. After ozonation, the acetic acid solution was diluted with water and extracted with ether. The ether extracts were washed with water, 5% sodium carbonate, dried (magnesium sulfate) and concentrated. Recrystallization from isopropanol gave 2.6 g. (47%) of product which melted at 133°-134° C.

Aufarbeitung

  1. extractionextracted with ether
  2. washThe ether extracts were washed with water, 5% sodium carbonate
  3. dry with materialdried (magnesium sulfate)
  4. concentrationconcentrated
  5. customRecrystallization from isopropanol
  6. customgave 2.6 g

Quellen und Nachweise

ORD-Eintrag
ord-f6ae27a9a5f04c889ad023b7cf9e42af
Quelldatensatz
uspto-grants-1977_08
Patentnummer
US04045576

Notizen zur Reaktion

Wird geladen…