Trichloroacetyl chloride → 2-(Trichloroacetyl)pyrrole

HRID 44255

Reaktionsgleichung

Reaktionsgleichung von HRID 44255
[Cl:1][C:2]([Cl:7])([Cl:6])[C:3](Cl)=[O:4].[NH:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1.C(=O)([O-])[O-].[K+].[K+]>C(OCC)C.O>[Cl:1][C:2]([Cl:7])([Cl:6])[C:3]([C:9]1[NH:8][CH:12]=[CH:11][CH:10]=1)=[O:4]

Komponenten

6

Edukt 3

HCID 6420Trichloroacetyl chlorideHCID 8027PyrroleHCID 11430Potassium Carbonate

Produkt 1

HCID 3214872-(Trichloroacetyl)pyrrole

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

To a solution of trichloroacetyl chloride (160.7 mmoles) in ethyl ether (26 ml) there is added, dropwise over a period of 3 hours, a solution of pyrrole (149 mmoles) in ethyl ether (83 ml). After stirring for a further hour, a solution of potassium carbonate (94 mmoles) in water (39 ml) is added dropwise. The phases are separated and the organic phase is dried over sodium sulphate and filtered. Active carbon is added to this organic phase. After stirring for 5 minutes, the organic phase is filtered and evaporated to dryness to yield the title product.

Aufarbeitung

  1. customThe phases are separated
  2. dry with materialthe organic phase is dried over sodium sulphate
  3. filtrationfiltered
  4. additionActive carbon is added to this organic phase
  5. stirringAfter stirring for 5 minutes
  6. filtrationthe organic phase is filtered
  7. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-c606efcc6d174fd5af17b1eca1f8b113
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541412B2

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