Potassium Hydroxide → 4-(m-Toluidino)-1-benzylpiperidine-4-carboxylic acid

HRID 443299Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 443299
[CH2:1]([N:8]1[CH2:16][CH2:15][C:11]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=2)([C:12](N)=[O:13])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:25].[K+]>C(O)CO.O.C(O)(=O)C>[CH2:1]([N:8]1[CH2:16][CH2:15][C:11]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=2)([C:12]([OH:25])=[O:13])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

6

Edukt 2

HCID 14797Potassium HydroxideHCID 211931981-Benzyl-4-(3-methylphenylamino)isonipecotamide

Produkt 1

HCID 211934454-(m-Toluidino)-1-benzylpiperidine-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 174Ethylene GlycolLösungsmittelHCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 1-benzyl-4-(3-methylphenylamino)-isonipecotamide (4.5 g, 13.9 mmol) and potassium hydroxide (3.g, 53.5 mmol) in ethylene glycol (35 mL) was heated under reflux. The resulting mixture was diluted with water and neutralized with acetic acid. The white solid precipitated was filtered, washed with chloroform to provide 1-benzyl-4-(3-methylphenylamino)piperidine-4-carboxylic acid.

Aufarbeitung

  1. temperatureunder reflux
  2. customThe white solid precipitated
  3. filtrationwas filtered
  4. washwashed with chloroform

Quellen und Nachweise

ORD-Eintrag
ord-7c1864e1d3a84e0fb738ef33ea8fc92a
Quelldatensatz
uspto-grants-1999_04
Patentnummer
US05891889

Notizen zur Reaktion

Wird geladen…