Sodium Cyanate → 1-cyclohexylmethyl-4-(4-isopropyl-phenyl)-6,7-dimethoxy-1H-quinazolin-2-one

HRID 445184

Reaktionsgleichung

Reaktionsgleichung von HRID 445184
[NH2:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH3:11])=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][C:17]([CH:20]([CH3:22])[CH3:21])=[CH:16][CH:15]=1)=O.[O-:23][C:24]#[N:25].[Na+]>C(O)(=O)C>[CH:3]1([CH2:12][N:1]2[C:2]3[C:3](=[CH:4][C:5]([O:10][CH3:11])=[C:6]([O:8][CH3:9])[CH:7]=3)[C:12]([C:14]3[CH:19]=[CH:18][C:17]([CH:20]([CH3:22])[CH3:21])=[CH:16][CH:15]=3)=[N:25][C:24]2=[O:23])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:2]1

Komponenten

4

Edukt 2

HCID 517096Sodium CyanateHCID 59259172(2-Amino-4,5-dimethoxy-phenyl)-(4-isopropyl-phenyl)-methanone

Produkt 1

HCID 101591391-cyclohexylmethyl-4-(4-isopropyl-phenyl)-6,7-dimethoxy-1H-quinazolin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution of 50 mg (0.126 mmol) (2-amino-4,5-dimethoxy-phenyl)-(4-isopropyl-phenyl)-methanone in 1 ml acetic acid are added 8 mg (0.126 mmol) sodium cyanate. After stirring for 24 h at rt the solvent is evaporated and the residue is extracted with dichloromethane/0.1 M NaOH. Recrystallisation from ether/hexanes yields the title compound.

Aufarbeitung

  1. customis evaporated
  2. extractionthe residue is extracted with dichloromethane/0.1 M NaOH
  3. customRecrystallisation from ether/hexanes

Quellen und Nachweise

ORD-Eintrag
ord-29066ebe71f347c19c134ecf0c9aa638
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08476286B2

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