Isopropyl isocyanate → N-Isopropyl-4,4-dimethyl-1-(4-(trifluoromethyl)phenyl)-3,4-dihydro-isoquinoline-2(1H)-carboxamide
Reaktionsgleichung
[CH3:1][C:2]1([CH3:22])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)[NH:4][CH2:3]1.[CH:23]([N:26]=[C:27]=[O:28])([CH3:25])[CH3:24]>ClCCCl>[CH:23]([NH:26][C:27]([N:4]1[CH2:3][C:2]([CH3:22])([CH3:1])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]1[C:12]1[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:19])[F:20])=[CH:14][CH:13]=1)=[O:28])([CH3:25])[CH3:24]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A 25-mL round-bottomed flask was charged with 4,4-dimethyl-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (366 mg, 1.2 mmol), iso-propyl isocyanate (141 μL, 1.4 mmol), DCE (5 mL) and stirred at RT for 1 h. Then the solvent was removed under vacuum and the product was purified by recrystallization from a mixture of ether/hexane. MS (ESI, positive ion) m/z: 391 (M+H).