Water → HCID 49766558, Verbindung

HRID 447050Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 447050
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[OH:11].[Br:12]Br.O>C(Cl)Cl>[NH2:1][C:2]1[C:7]([Br:12])=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[OH:11]

Komponenten

5

Edukt 3

HCID 962WaterHCID 24408BromineHCID 49847212-Amino-5-Nitrophenol

Produkt 1

HCID 49766558HCID 49766558, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To an ice-cold solution of 2-amino-5-nitro phenol (40.0 g, 259.52 mmol) in DCM (1.0 L), was added bromine (13.38 mL, 259.52 mmol) drop wise. The resulting reaction mixture was stirred at room temperature for 45 min. After the completion of the reaction (TLC monitoring), water was added and extracted with EtOAc (3×1.0 L). The combined organics was dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude (55.0 g, 92%) was carried forward to the next step without further purification.

Aufarbeitung

  1. customThe resulting reaction mixture
  2. additionwas added
  3. extractionextracted with EtOAc (3×1.0 L)
  4. dry with materialThe combined organics was dried over anhydrous Na2SO4
  5. concentrationconcentrated under reduced pressure
  6. customThe crude (55.0 g, 92%) was carried forward to the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-ccc715c7f9624efbb093031d5b468986
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08481544B2

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